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The effects of 6-hydroxydopamine pretreatment on the accumulation of dopa and dopamine in brain and peripheral organs following l-dopa administration

✍ Scribed by L. D. Lytle; O. Hurko; J. A. Romero; K. Cottman; D. Leehey; R. J. Wurtman

Publisher
Springer
Year
1972
Tongue
English
Weight
517 KB
Volume
33
Category
Article
ISSN
1435-1463

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## Abstract Ever since the introduction of levo‐3, 4‐dihydroxyphenylalanine (L‐dopa) for the treatment of Parkinson's disease, there has been concern that it might accelerate the degeneration of dopamine neurones. Using rats with a unilateral 6‐hydroxydopamine (6‐OHDA) lesion of the medial forebrai