Effects of water deprivation for 72 hours on the pharmacokinetics of a new carbapenem, DA-1131, in rats
โ Scribed by So Hee Kim; Jong Won Kwon; Won Bae Kim; Inchul Lee; Myung Gull Lee
- Book ID
- 117173708
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 100 KB
- Volume
- 71
- Category
- Article
- ISSN
- 0024-3205
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๐ SIMILAR VOLUMES
The nephroprotective effect of betamipron (200 mg/kg) was evaluated after intravenous administration of a high dose of DA-1131 (200 mg/kg) to rabbits. Extensive tubular necrosis was observed without betamipron but the necrosis was not observed with betamipron at 8 h after intravenous administration
The total body clearance (CI), renal clearance (CIr), and apparent volume of distribution at steady state (Vss) of DA-1131, a new carbapenem, after intravenous (iv) administration of the drug, 50 mg kg-1, to mice, rats, rabbits, and dogs were analysed as a function of species body weight (W) using t