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Pharmacokinetics of omeprazole in rats with water deprivation for 72 hours

โœ Scribed by Dae Y. Lee; Hyun S. Shin; Inchul Lee; Myung G. Lee

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
139 KB
Volume
27
Category
Article
ISSN
0142-2782

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## Abstract It was reported that metformin was mainly metabolized via hepatic CYP2C11, 2D1 and 3A1/2 in rats, and in a rat model of dehydration, the expressions of hepatic CYP2C11 and 3A1/2 were not changed. Hence, it could be expected that the __Cl__~nr~ of metformin is comparable between two grou