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Simultaneous determination of amantadine and rimantadine by HPLC in rat plasma with pre-column derivatization and fluorescence detection for pharmacokinetic studies

✍ Scribed by Yasuhiko Higashi; Izumi Uemori; Youichi Fujii


Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
188 KB
Volume
19
Category
Article
ISSN
0269-3879

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A simple and sensitive HPLC method has been developed for the simultaneous determination of enrofloxacin (ENR) and ciprofloxacin (CIP) in plasma. Plasma sample preparation was carried out by adding phosphate buffer (pH 7.4, 0.1 M), followed by extraction with trichloromethane. ENR, CIP and the inter