Effects of tumour necrosis factor on protein metabolism
✍ Scribed by D. A. Evans; D. O. Jacobs; Dr D. W. Wilmore
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 592 KB
- Volume
- 80
- Category
- Article
- ISSN
- 0007-1323
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Tumonr necrosis factor alpha (TNF~) effectively stimulates the oxidative metabolism of human PMN in vitro. Moreover, preincnbation of PMN with TNF~ has been shown to result in an altered response of the target cells to subsequent stimulation. In the present study the response of PMN to stimulation i
Activation of PMN leucocytes was monitored by the luminol chemiluminescence (CL) method. PMNs were preincubated with or without tumour necrosis factor (TNF) and stimulated by latex (standard) or latex coated with native or oxidized proteins. As a modifying agent hypochlorite was used. The time cours