Acute treatment with tumour necrosis factor-α induces changes in protein metabolism in rat skeletal muscle

Tumor necrosis factor-α–induced apoptosi

Tumor necrosis factor-α–induced apoptosis is associated with suppression of insulin-like growth factor binding protein-5 secretion in differentiating murine skeletal myoblasts

✍ Kate A. Meadows; Jeff M.P. Holly; Claire E.H. Stewart 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 264 KB 👁 1 views

Wasting of muscle and fat during cachexia exceeds that explained by reduced food intake alone. This wasting may result from an imbalanced cytokine environment, which could lead to increased protein catabolism. Supporting this, tumor necrosis factor-alpha (TNF-alpha) is raised in several animal model