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Effects of trepelennamine on brain monoamine turnover in morphine dependent and abstinent mice

✍ Scribed by O. San-Martín-Clark; B. Cuéllar; J. -C. Leza; I. Lizasoain; P. Lorenzo

Publisher
Springer
Year
1996
Tongue
English
Weight
606 KB
Volume
123
Category
Article
ISSN
0033-3158

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Mice were treated for 14 days with clonazepam, 0.5 mg/kg i.p. twice daily, during which time partial tolerance to the anticonvulsant effect against pentetrazole developed. The development of tolerance was paralleled by a reduced turnover of noradrenaline in the whole brain, and of dopamine in the mi