The rat tracheal implant model was used to characterize the role of activated Ha-ras in the neoplastic progression of heterogeneous rat tracheal epithelial (RTE) cell populations. An activated Ha-ras-containing cell line, RTE 2-2, and its subclone, RTE 2-2n, which possesses only Ha-ras proto-oncogen
โฆ LIBER โฆ
Effects of the activated Ki-ras expression on thyroid epithelial cells in vivo and in vitro
โ Scribed by Califano, D.; Santelli, G.; de Franciscis, V.; Chiappetta, G.; Monaco, C.; D'Alessio, A.; Mineo, A.; Manzo, G.; Vecchio, G.
- Book ID
- 122879028
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 187 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0959-8049
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## Abstract We previously demonstrated a high incidence of ras mutation in thyroid follicular (epithelial) cell neoplasms and showed that expression of mutant ras is a potent mitogenic stimulus for normal human follicular cells in culture. Here we show that induction of cell proliferation in primar