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Effects of somatostatin on inositol-1,4,5-trisphosphate content in mouse spleen lymphocytes

✍ Scribed by Lachowicz, Agnieszka; Stȩpień, Henryk; Kunert-Radek, Jolanta; Pawlikowski, Marek

Book ID: 122382749
Publisher: Elsevier Science
Year: 1992
Tongue: English
Weight: 362 KB
Volume: 101
Category: Article
ISSN: 0300-9629
DOI: 10.1016/0300-9629(92)90340-V

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## Abstract Inositol 1,4,5‐trisphosphate receptors (IP~3~R) are ligand‐gated intracellular Ca^2+^channels that mediate release of Ca^2+^ from intracellular stores into the cytosol on activation by second messenger IP~3~. Similarly, IP~3~R mediated changes in cytosolic Ca^2+^ concentrations control