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Effects of pyridoxine on the intestinal absorption and pharmacokinetics of isoniazid in rats

✍ Scribed by Yan Zhou, Yang Jiao, Yu-Hui Wei…

Book ID
120721239
Publisher
Springer-Verlag
Year
2012
Tongue
English
Weight
394 KB
Volume
38
Category
Article
ISSN
0378-7966

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Tuberculosis chemotherapy involves combination of the drugs isoniazid (INH), rifampicin (RMP) and pyrazinamide (PYR) for a 6-month period. The present work investigated the influence of RMP and PYR on the pharmacokinetic parameters of INH when groups of rats were pre-treated for 21 days with INH alo