Effects of Organic Solvents on Immobilized Lipase in Pectin Microspheres
β Scribed by L. Costas; V. E. Bosio; A. Pandey; G. R. Castro
- Book ID
- 107564926
- Publisher
- Springer-Verlag
- Year
- 2008
- Tongue
- English
- Weight
- 208 KB
- Volume
- 151
- Category
- Article
- ISSN
- 0273-2289
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Lipase from Candida rugosa immobilized on a nylon support has been used to synthesize lovastatin, a drug which lowers serum cholesterol levels, by the regioselective acylation of a diol lactone precursor with 2methylbutyric acid in mixtures of organic solvents. Analogs of lovastatin having a differe
The e β ects of polyols and organic solvents on the thermostability of lipase were studied. The thermodeactivation process of lipase obeyed a series deactivation model and four kinetic parameters were determined. The rate constant of the Γrst deactivation process was found to be a key one. All the po