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Effects of obesity induced by high-fat diet on the pharmacokinetics of cyclosporine A in rats

✍ Scribed by Keizo Fukushima; Kosuke Yoshida; Yukako Ito; Kanji Takada; Nobuyuki Sugioka

Book ID
119196138
Publisher
Elsevier
Year
2011
Tongue
English
Weight
302 KB
Volume
1
Category
Article
ISSN
2210-5239

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✍ Nobuyuki Sugioka; Kenta Haraya; Keizo Fukushima; Yukako Ito; Kanji Takada πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 142 KB πŸ‘ 2 views

## Abstract The effect of obesity induced by a high‐fat diet on the pharmacokinetics (PK) of nelfinavir (NFV) was investigated, focusing on the change of distribution and elimination caused by dyslipidemia and hepatic steatosis. The plasma unbound fraction (__f__~u~) of NFV in obese rats (0.61Β±0.0