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Effects of Dietary Lactose on Long-term High-fat-diet-induced Obesity in Rats

✍ Scribed by Masae Goseki-Sone; Rieko Maruyama; Natsuko Sogabe; Takayuki Hosoi


Book ID
109968775
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
516 KB
Volume
15
Category
Article
ISSN
1930-7381

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## Abstract The effect of obesity induced by a high‐fat diet on the pharmacokinetics (PK) of nelfinavir (NFV) was investigated, focusing on the change of distribution and elimination caused by dyslipidemia and hepatic steatosis. The plasma unbound fraction (__f__~u~) of NFV in obese rats (0.61Β±0.0