High fat diet-induced obesity modifies the methylation pattern of leptin promoter in rats
✍ Scribed by F. I. Milagro; J. Campión; D. F. García-Díaz; E. Goyenechea; L. Paternain; J. A. Martínez
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 213 KB
- Volume
- 65
- Category
- Article
- ISSN
- 1138-7548
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Diet-induced obesity in rats can be produced by high-fat feeding. Comparing high-fat with low-fat feeding, the present study was designed to characterize the phases ofdevelopment ofobesity. In the dynamic phase, male rats were investigated at the age of 9-10 weeks after feeding the diets for 4-5 wee
## Abstract The effect of obesity induced by a high‐fat diet on the pharmacokinetics (PK) of nelfinavir (NFV) was investigated, focusing on the change of distribution and elimination caused by dyslipidemia and hepatic steatosis. The plasma unbound fraction (__f__~u~) of NFV in obese rats (0.61±0.0