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Effect of protamine in obesity induced by high-fat diets in rats

✍ Scribed by Duarte-Vázquez, MÁ; García-Padilla, S; Olvera-Ochoa, L; González-Romero, K E; Acosta-Íñiguez, J; De la Cruz-Cordero, R; Rosado, J L

Book ID
109866620
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
114 KB
Volume
33
Category
Article
ISSN
1476-5497

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## Abstract The effect of obesity induced by a high‐fat diet on the pharmacokinetics (PK) of nelfinavir (NFV) was investigated, focusing on the change of distribution and elimination caused by dyslipidemia and hepatic steatosis. The plasma unbound fraction (__f__~u~) of NFV in obese rats (0.61±0.0