𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Effects of nootropic drugs in a scopolamine-induced amnesia model in mice

✍ Scribed by R. Verloes; A.-M. Scotto; J. Gobert; E. Wülfert

Publisher
Springer
Year
1988
Tongue
English
Weight
455 KB
Volume
95
Category
Article
ISSN
0033-3158

No coin nor oath required. For personal study only.

✦ Synopsis

Scopolamine (3 mg/kg IP) given before an acquisition trial, reduced the retention of a one-trial passive avoidance "step through" response in mice. A single administration of cholinergic agonists such as oxotremorine, BM-5, or arecoline, antagonized this amnesic effect of scopolamine. A significant anti-amnesic effect was also found with nootropic drugs such as piracetam and ucb L059, whereas ucb L060 (the enantiomer of ucb L059), oxiracetam and rolziracetam were shown to be ineffective. Moreover, ucb L059, administered twice daily for 3 days, counteracted the amnesic effects of scopolamine completely, whereas ucb L060 was again inactive. The results demonstrate that: (a) this model of impaired cognition by scopolamine is able to discriminate between closely related chemical substances and even stereoisomers; and (b) nootropic drugs, such as ucb L059, are more effective after repeated rather than after acute administration.

📜 SIMILAR VOLUMES

Attenuation of scopolamine-induced amnes
Attenuation of scopolamine-induced amnesia in mice
✍ William S. Stone; Carolyn E. Croul; Paul E. Gold 📂 Article 📅 1988 🏛 Springer 🌐 English ⚖ 413 KB

Numerous studies suggest that age-related declines in memory storage are related to impairment of central cholinergic systems. Scopolamine, a muscarinic cholinergic antagonist, has been used with young humans and other animal species as a model of the cognitive impairment that often accompanies norm

Scopolamine-induced locomotor stimulatio
Scopolamine-induced locomotor stimulation in mice: Effect of diazepam and a benzodiazepine antagonist
✍ Mario Sansone 📂 Article 📅 1982 🏛 Springer 🌐 English ⚖ 195 KB

The benzodiazepine diazepam and the benzodiazepine antagonist Ro 15-1788 were tested alone or in combination for their influence on scopolamine-induced locomotor stimulation in mice. The benzodiazepine antagonist had no effect by itself, but prevented the enhancement of scopolamine-induced locomotor

Effects of anticonvulsant drugs on 4-ami
Effects of anticonvulsant drugs on 4-aminopyridine-induced seizures in mice
✍ Shun-ichi Yamaguchi; Michael A. Rogawski 📂 Article 📅 1992 🏛 Elsevier Science 🌐 English ⚖ 645 KB

The K+ channel blocker 4-aminopyridine (4-AP) causes epileptiform activity in in vitro preparations and is a potent convulsant in animals and man. In mice, 4-AP produces behavioral activation, clonic limb movements and wild running, followed by tonic hindlimb extension and death (ED97, 13.3 mg/kg, s