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Effect of serotoninergic drugs on stress-induced hyperthermia (SIH) in mice

โœ Scribed by A. Lecci; F. Borsini; A. Mancinelli; V. D'Aranno; M. A. Stasi; G. Volterra; A. Meli


Publisher
Springer
Year
1990
Tongue
English
Weight
790 KB
Volume
82
Category
Article
ISSN
1435-1463

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The K+ channel blocker 4-aminopyridine (4-AP) causes epileptiform activity in in vitro preparations and is a potent convulsant in animals and man. In mice, 4-AP produces behavioral activation, clonic limb movements and wild running, followed by tonic hindlimb extension and death (ED97, 13.3 mg/kg, s