Scopolamine-induced locomotor stimulation in mice: Effect of diazepam and a benzodiazepine antagonist
β Scribed by Mario Sansone
- Publisher
- Springer
- Year
- 1982
- Tongue
- English
- Weight
- 195 KB
- Volume
- 77
- Category
- Article
- ISSN
- 0033-3158
No coin nor oath required. For personal study only.
β¦ Synopsis
The benzodiazepine diazepam and the benzodiazepine antagonist Ro 15-1788 were tested alone or in combination for their influence on scopolamine-induced locomotor stimulation in mice. The benzodiazepine antagonist had no effect by itself, but prevented the enhancement of scopolamine-induced locomotor stimulation produced by diazepam.
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The effect of shock on locomotor activity was evaluated in three strains of mice (A, DBA/2 and C57BL/6) after treatment with scopolamine (1.0 mg/kg) and d-amphetamine (10.0 mg/kh). The effectiveness of either drug in incrasing locomotor activity was strain dependent. Both drugs eliminated behavioral
Scopolamine (3 mg/kg IP) given before an acquisition trial, reduced the retention of a one-trial passive avoidance "step through" response in mice. A single administration of cholinergic agonists such as oxotremorine, BM-5, or arecoline, antagonized this amnesic effect of scopolamine. A significant