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Effects of neonatal 6-hydroxydopamine lesion on the gene expression profile in young adult rats

โœ Scribed by Yoshinori Masuo; Masami Ishido; Masatoshi Morita; Syuichi Oka


Book ID
117473348
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
113 KB
Volume
335
Category
Article
ISSN
0304-3940

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The intrastriatal injection of 6-hydroxydopamine (6-OHDA) in newborn rats produces a marked striatal dopamine (DA) depletion, accompanied by a serotonin (5-HT) hyperinnervation and an up-regulation of 5-HT receptors. The aim of the present study was to investigate whether the increase in 5-HT 2 rece