Exposure of cultured human breast cancer cells (MCF-7) to medroxyprogesterone acetate (MPA) prior to treatment with adriamycin (ADR) enhanced the effect of the cytotoxic drug on cell yield after further growth of viable cells. Pretreatment with oestradiol (E2) produced similar synergism, but no such
Effects of Medroxyprogesterone Acetate on Human Breast Cancer Cells in Culture
โ Scribed by HANNELORE BRAUNSBERG; ROSEMARY C. BONNEY
- Book ID
- 118723193
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 176 KB
- Volume
- 464
- Category
- Article
- ISSN
- 0890-6564
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Human breast cancer cells (MCF-7) showed increased responses to methotrexate and vincristine after a 48-hr pretreatment with medroxyprogesterone acetate. The effect of the hormone, which was detectable at concentrations of between 10 and IOOnM, was independent of its growth-inhibitory action. These
From clinical experience it is known that medroxyprogesterone acetate (MPA) can increase 'the radiosensitivity of adenocarcinomas of the corpus uteri. This study investigates this phenomenon in vitro. Primary explants of highly differentiated adenocarcinomas were irradiated with or without pretreatm