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Androgen receptor agonist activity of the synthetic progestin, medroxyprogesterone acetate, in human breast cancer cells

✍ Scribed by Jacqueline M Bentel; Stephen N Birrell; Marie A Pickering; Duncan J Holds; David J Horsfall; Wayne D Tilley

Book ID: 117464240
Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 200 KB
Volume: 154
Category: Article
ISSN: 0303-7207
DOI: 10.1016/s0303-7207(99)00109-4

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Human breast cancer cells (MCF-7) showed increased responses to methotrexate and vincristine after a 48-hr pretreatment with medroxyprogesterone acetate. The effect of the hormone, which was detectable at concentrations of between 10 and IOOnM, was independent of its growth-inhibitory action. These