✦ LIBER ✦

Actions of medroxyprogesterone acetate on the efficacy of cytotoxic drugs: Studies with human breast cancer cells in culture

✍ Scribed by Naeem A. Shaikh; Alison M. Owen; Margaret W. Ghilchik; Hannelore Braunsberg

Publisher: John Wiley and Sons
Year: 1989
Tongue: French
Weight: 632 KB
Volume: 43
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910430319

No coin nor oath required. For personal study only.

✦ Synopsis

Human breast cancer cells (MCF-7) showed increased responses to methotrexate and vincristine after a 48-hr pretreatment with medroxyprogesterone acetate. The effect of the hormone, which was detectable at concentrations of between 10 and IOOnM, was independent of its growth-inhibitory action. These findings confirm a previous clinical study and have important implications with regard to the management of advanced breast cancer.

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