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Effects of low frequency pulsed electrical current on keratinocytes in vitro

โœ Scribed by M. Hinsenkamp; A. Jercinovic; Ch. de Graef; F. Wilaert; M. Heenen


Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
253 KB
Volume
18
Category
Article
ISSN
0197-8462

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โœฆ Synopsis


The effects of low frequency pulsed electrical current on epidermal repair in vitro were examined. Chargebalanced current stimuli proposed for chronic wound treatment were tested on skin keratinocytes cultured at an air-liquid interface on dead human dermis. Results imply that the balance between proliferation and differentiation in electrically treated samples is significantly modified in favor of differentiation. More advanced differentiation, shown through epidermal histology, was obtained in cultures exposed to electrical current, whereas the culture growth, the result of keratinocyte migration and proliferation, was greater in control samples.


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