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Effects of HIV-1 Tat protein on human T cell proliferation

✍ Scribed by Linde Meyaard; Sigrid A. Otto; Hanneke Schuitemaker; Frank Miedema

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
477 KB
Volume
22
Category
Article
ISSN
0014-2980

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✦ Synopsis

In inducing immunodeficiency in human immunodeficiency virus (HIV)-l infection, a role for the HIV-1 Tat protein has been suggested. In addition to effects on viral transcription, the protein has been ascribed immunosuppressive functions, which were investigated in this study. Proliferation of purified T cells to CD3 monoclonal antibodies immobilized to plastic plates was inhibited up to 70% by addition of 5 yglml of the Tat protein. This inhibitory effect, however, was not observed in the presence of accessory cells. Furthermore, no effect of Tat protein could be observed on T cell proliferative responses to recall antigen which most likely is related to the presence of accessory cells in the cultures. Taken together, our results do not imply an important role for immunosuppressive effects of Tat in induction of immunodeficiency as observed in HIV infection in vivo.

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