𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Effects of growth hormone and nutrient on limb regeneration in hypophysectomized adult newts

✍ Scribed by Norimitsu L. Sato; Sakae Inoue

Publisher
John Wiley and Sons
Year
1973
Tongue
English
Weight
713 KB
Volume
140
Category
Article
ISSN
0362-2525

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The effect of hypophysectomy, growth hormone (GH) and an amino acid‐glucose mixture on the regenerative ability of the hypophysectomized Triturus pyrrhogaster yielded the following results:

The survival time of hypophysectomized newts can be prolonged substantially by the sulfamide application.

Although the limb regeneration in the hypophysectomized newt is retarded as compared with that of the pituitary intact control, it finally completes morphogenetic process under such conditions of prolonged survival.

The injection of 100 ΞΌg of GH restored the speed of regeneration of pituitary‐deprived limbs to almost a normal level.

Injections of the amino acid‐glucose mixture also promoted the limb regeneration in hypophysectomized newts. However, initial delay in regeneration to the time of bud appearance was not restored by the nutrients.

πŸ“œ SIMILAR VOLUMES

Effect of a highly purified growth hormo
Effect of a highly purified growth hormone on limb regeneration in the hypophysectomized newt,Notophthalmus viridescens
✍ Bromley, Stephen C ;Thornton, Charles S πŸ“‚ Article πŸ“… 1974 πŸ› John Wiley and Sons 🌐 English βš– 857 KB

## Abstract Preparations of ungulate growth hormone that have been used thus far to establish the role of that compound in supporting limb regeneration in hypophysectomized newts have contained significant prolactin contamination. Prolactin when present with thyroxin has been shown to be effective

Bioengineered human growth hormone suppo
Bioengineered human growth hormone supports limb regeneration in the hypophysectomized newtNotophthalmus viridescens
✍ Landesman, Richard H. ;Copeland, Kenneth C. πŸ“‚ Article πŸ“… 1988 πŸ› John Wiley and Sons 🌐 English βš– 374 KB

It is well documented that growth hormone (GH) replacement therapy will restore normal limb regeneration to hypophysectomized adult newts. However, it is also known that the GH preparations used in previous reports were contaminated by other pituitary hormones shown to support regeneration when admi