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Effect of a highly purified growth hormone on limb regeneration in the hypophysectomized newt,Notophthalmus viridescens

✍ Scribed by Bromley, Stephen C ;Thornton, Charles S

Publisher: John Wiley and Sons
Year: 1974
Tongue: English
Weight: 857 KB
Volume: 190
Category: Article
ISSN: 0022-104X
DOI: 10.1002/jez.1401900204

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✦ Synopsis

Abstract

Preparations of ungulate growth hormone that have been used thus far to establish the role of that compound in supporting limb regeneration in hypophysectomized newts have contained significant prolactin contamination. Prolactin when present with thyroxin has been shown to be effective at low doses in supporting limb regeneration in these animals. The present communication demonstrates that a highly purified preparation of bovine growth hormone is able to support limb regeneration in hypophysectomized newts at essentially normal levels. Previous results indicating that prolactin and thyroxin in combination restore the regenerative response are corroborated. Thyroxin alone, or prolactin alone, gave a much reduced response. Purified growth hormone, while effective alone, is apparently antagonized by the presence of thyroxin.

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