✦ LIBER ✦
Bioengineered human growth hormone supports limb regeneration in the hypophysectomized newtNotophthalmus viridescens
✍ Scribed by Landesman, Richard H. ;Copeland, Kenneth C.
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 374 KB
- Volume
- 248
- Category
- Article
- ISSN
- 0022-104X
No coin nor oath required. For personal study only.
✦ Synopsis
It is well documented that growth hormone (GH) replacement therapy will restore normal limb regeneration to hypophysectomized adult newts. However, it is also known that the GH preparations used in previous reports were contaminated by other pituitary hormones shown to support regeneration when administered free of GH. The recent availability of bioengineered human GH was studied for its ability to restore the regenerative capacity to hypophysectomized newts.
Five days posthypophysectomy adult newts were subject to forelimb amputation distal to the elbow.