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Effects of griseofulvin on apoptosis through caspase-3- and caspase-9-dependent pathways in K562 leukemia cells: An in vitro study

✍ Scribed by Ning Zhong; Hankui Chen; Quanlin Zhao; Hongwei Wang; Xin Yu; Ashley M. Eaves; Weihua Sheng; Jingcheng Miao; Fengmei Cui; Jinzhi Wang

Book ID
117090900
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
421 KB
Volume
71
Category
Article
ISSN
0011-393X

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## Abstract Exogenous Ξ²~2~‐microglobulin (Ξ²~2~m) induces significant apoptosis in the CCRF‐HSB‐2 human lymphoblastic leukemia cell line as detected by DNA fragmentation, DAPI staining and annexin V binding assay. Ξ²~2~m treatment induced the release of cytochrome c and apoptosis‐inducing factor (AIF