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Inactivation of PI3k/Akt signaling pathway and activation of caspase-3 are involved in tanshinone I-induced apoptosis in myeloid leukemia cells in vitro

โœ Scribed by Jia-Jun Liu; Wen-Da Liu; Hong-Zhi Yang; Yong Zhang; Zhi-Gang Fang; Pei-Qing Liu; Dong-Jun Lin; Ruo-Zhi Xiao; Yuan Hu; Chun-Zhi Wang; Xu-Dong Li; Yi He; Ren-Wei Huang

Publisher
Springer
Year
2010
Tongue
English
Weight
620 KB
Volume
89
Category
Article
ISSN
0939-5555

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## Abstract Ursolic acid (UA), a pentacyclic triterpenoid compound, has been demonstrated to have an antiproliferative effect in various tumors. We investigated the cell killing effects of UA in the human hormone refractory prostate cancer cell line, PCโ€3 cells. Also, the molecular mechanisms under