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Effects of geranyl-phloroacetophenone on the induction of apoptosis and chemosensitization of adriamycin-resistant MCF-7 human breast cancer cells

✍ Scribed by Cho, Mi-Yeon; Park, Su-Young; Park, Sumin; Lee, Yong Rok; Kwak, Mi-Kyoung; Kim, Jung-Ae


Book ID
113100945
Publisher
Springer
Year
2012
Tongue
English
Weight
938 KB
Volume
35
Category
Article
ISSN
0253-6269

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In this study the ability of the new pure anti-estrogen IcI 182,780 to modulate the cytotoxic action of adriamycin (ADR) on parental and ADR-resistant MCF-7 (MCF-7 ADRr) human breast-cancer cells was investigated and compared with that of tamoxifen (TAM). TAM enhanced ADR cytotoxicity in MCF-7 ADRr