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Chemosensitizing Effect of Tamoxifen and ICI 182,780 on Parental and Adriamycin-resistant MCF-7 Human Breast Cancer Cells

✍ Scribed by R. DE VINCENZO; G. SCAMBIA; P. BENEDETTI PANICI; G. BONANNO; A. ERCOLI; A. FATTOROSSI; S. PERNISCO; G. ISOLA; S. MANCUSO


Book ID
119872769
Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
195 KB
Volume
784
Category
Article
ISSN
0890-6564

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πŸ“œ SIMILAR VOLUMES


Modulatory effect of tamoxifen and ICI 1
✍ Rosa De Vincenzo; Giovanni Scambia; Pierluigi Benedetti Panici; Andrea Fattoross πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 French βš– 865 KB

In this study the ability of the new pure anti-estrogen IcI 182,780 to modulate the cytotoxic action of adriamycin (ADR) on parental and ADR-resistant MCF-7 (MCF-7 ADRr) human breast-cancer cells was investigated and compared with that of tamoxifen (TAM). TAM enhanced ADR cytotoxicity in MCF-7 ADRr

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The effects of the anti-estrogens 4-hydroxytamoxifen (OHTam), ICI 164,384 and ICI 182,780 were tested on the MCF-7/LCC2 breast-carcinoma cell line, which grows significantly in the presence of OHTam and serves as a model for studying anti-estrogen resistance of estrogen-receptor-positive breast canc