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Effects of Estrogen Coadministration on Epoxiconazole Toxicity in Rats

✍ Scribed by Stinchcombe, Stefan; Schneider, Steffen; Fegert, Ivana; Rey Moreno, Maria Cecilia; Strauss, Volker; Gröters, Sibylle; Fabian, Eric; Fussell, Karma C.; Pigott, Geoffrey H.; van Ravenzwaay, Bennard

Book ID
121299164
Publisher
John Wiley and Sons
Year
2013
Tongue
English
Weight
159 KB
Volume
98
Category
Article
ISSN
1542-9733

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The cardiotoxic and neurotoxic effects of tegafur, an anticancer agent, were compared with those of uracil plus tegafur (4:1 mol/mol) in mice, rats, rabbits, cats and dogs. Uracil plus tegafur was shown to be less toxic than the drug alone in all the species, and uracil was found to decrease the tox