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Effect of coadministration of uracil on the toxicity of tegafur

✍ Scribed by Jyunji Yamamoto; Akihiro Haruno; Yuji Yoshimura; Norio Unemi; Yoshio Kunimune; Kazumasa Yamashita; Ken'Ichi Morita

Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
369 KB
Volume
73
Category
Article
ISSN
0022-3549

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✦ Synopsis

The cardiotoxic and neurotoxic effects of tegafur, an anticancer agent, were compared with those of uracil plus tegafur (4:1 mol/mol) in mice, rats, rabbits, cats and dogs. Uracil plus tegafur was shown to be less toxic than the drug alone in all the species, and uracil was found to decrease the toxicity of tegafur. alpha-Fluoro-beta-alanine, a catabolic metabolite of the drug, had toxic effects similar to tegafur. The results suggest that administration of uracil with tegafur prevents the side effects of the drug on the heart and CNS by inhibiting the degradation of 5-fluorouracil.

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