The cardiotoxic and neurotoxic effects of tegafur, an anticancer agent, were compared with those of uracil plus tegafur (4:1 mol/mol) in mice, rats, rabbits, cats and dogs. Uracil plus tegafur was shown to be less toxic than the drug alone in all the species, and uracil was found to decrease the tox
โฆ LIBER โฆ
Effect of deoxyuridine coadministration on toxicity and antitumor activity of fluorouracil and floxuridine
โ Scribed by Johnson G. Jato; Lanny M. Lake; Edward E. Grunden; Bruce M. Johnson
- Publisher
- John Wiley and Sons
- Year
- 1975
- Tongue
- English
- Weight
- 444 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0022-3549
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The new monomer, 3,6-endo-methylene-1,2,3,6-tetrahydrophthalimidoethanoyl-5-fluorouracil (ETEFU), was synthesized from 5-fluorouracil (5-FU) and 3,6endo-methylene-1,2,3,6-tetrahydophthalimidoethanoyl chloride (ETEC). Its homopolymer and copolymers with acrylic acid (AA) and vinyl acetate (VAc) were