Toxicity and antitumor activity of 5-fluorouracil in combination with leucovorin. Role of dose schedule and route of administration of leucovorin
โ Scribed by Youcef M. Rustum
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 440 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0008-543X
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๐ SIMILAR VOLUMES
## Background: Colorectal carcinoma is the third leading cause of cancer-related death. the primary treatment for patients with metastatic colorectal carcinoma is systemic chemotherapy with 5-fluorouracil (5-fu) and leucovorin (lv), a biomodulator of 5-fu that has been shown to enhance its activity
Conducted as a collaborative trial of North Central Cancer Treatment Group and Mayo Clinic.
Mature and post-translational precursor gastrin forms are growth factors for colorectal tumours. The immunogen Gastrimmune is composed of the amino terminus of gastrin-17 linked to diphtheria toxoid and raises antibodies in situ which neutralise amidated and glycine-extended gastrin-17. The aim of t