Transforming growth factor-alpha (TGFβ£) is an epidermal growth factor receptor (EGFR) ligand which is distinguished from EGF by its acid-labile structure and potent transforming function. We recently reported that TGFβ£ induces less efficient EGFR heterodimerization and downregulation than does EGF (
Effects of epidermal growth factor and transforming growth factor alpha on the function of wool follicles in culture
β Scribed by J. J. Bond; P. C. Wynn; G. P. M. Moore
- Publisher
- Springer-Verlag
- Year
- 1996
- Tongue
- English
- Weight
- 485 KB
- Volume
- 288
- Category
- Article
- ISSN
- 0340-3696
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We have investigated the actions of transforming growth factor (TGF) type a on epidermal growth factor (EGF) receptor mRNA expression in MDA-468 human mammary carcinoma cells in serum-free media. We found that exposure of MDA-468 cells to TGFa results in elevated levels of EGF receptor mRNA. This in
AMBER v. 4.1 force field in 1.5 ns NPT molecular dynamics simulations of murine epidermal growth factor (mEGF), human epidermal growth factor (hEGF), and human transforming growth factor-β£ (hTGF-β£) structures with explicit TIP3P solvation were used to investigate differences in backbone stability, c