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Effects of Doxorubicin (Adriamycin) and [(+)-1,2-Bis(3,5-dioxopiperazinyl-1-yl)]propane (ICRF-187) on Skeletal Muscle Protease Activities

✍ Scribed by Tomas Zima; Vladimir Tesar; Peter J. Richardson; David Mantle; Victor R. Preedy


Book ID
112267276
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
60 KB
Volume
171
Category
Article
ISSN
0041-008X

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High-performance liquid chromatography (HPLC) and fast atom bombardment mass spectrometry (FAB-MS) were employed to separate and identify the aqueous decomposition products of (+)1,2-bis(3,5-dioxopiperazinyl-1-yl)-propane (ICRF-187; 1), a drug active against several forms of human cancer and which a