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Bisdioxopiperazine, (+)-1,2-Bis(3,5-Dioxopiperazinyl-1-yl)propane (ICRF 187), Enhances the Antiproliferative Effect of Cisplatin on Human Ovarian Cancer Cells

✍ Scribed by G. Scambia; R.Della Bitta; P.Benedetti Panici; R. De Vincenzo; G. Contu; A. Ercoli; G. Bonanno; L. Pierelli; S. Mancuso


Book ID
115616495
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
279 KB
Volume
57
Category
Article
ISSN
0090-8258

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High-performance liquid chromatography (HPLC) and fast atom bombardment mass spectrometry (FAB-MS) were employed to separate and identify the aqueous decomposition products of (+)1,2-bis(3,5-dioxopiperazinyl-1-yl)-propane (ICRF-187; 1), a drug active against several forms of human cancer and which a