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An HPLC and spectrophotometric study of the hydrolysis of ICRF-187 (dexrazoxane, (+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane) and its one-ring opened intermediates

✍ Scribed by Brian B. Hasinoff


Book ID
113367803
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
793 KB
Volume
107
Category
Article
ISSN
0378-5173

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High-performance liquid chromatography (HPLC) and fast atom bombardment mass spectrometry (FAB-MS) were employed to separate and identify the aqueous decomposition products of (+)1,2-bis(3,5-dioxopiperazinyl-1-yl)-propane (ICRF-187; 1), a drug active against several forms of human cancer and which a