The present study used autoradiography to examine the effects of chronic self-administration of cocaine on the density of dopamine D 2 receptors in nonhuman primates. Three rhesus monkeys intravenously self-administered an average of 1.35 mg/kg cocaine per day for 18-22 months until they were euthan
Effects of dopamine receptor antagonists (D1 and D2) on the demand for smoked cocaine base in rhesus monkeys
β Scribed by U. C. Campbell; Joshua S. Rodefer; Marilyn E. Carroll
- Publisher
- Springer
- Year
- 1999
- Tongue
- English
- Weight
- 81 KB
- Volume
- 144
- Category
- Article
- ISSN
- 0033-3158
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
An array of evidence indicates that long-term exposure to cocaine alters several components of the brain dopamine system. Because the release of dopamine in the nucleus accumbens (NAc) has been implicated in mediating the reinforcing effects of cocaine, changes in dopamine function can have profound
To investigate the role of D, dopamine receptors in the discriminative stimulus effects of cocaine, two rhesus monkeys were trained in a two-lever, food-reinforced, drug discrimination paradigm to discriminate cocaine (0.2 rag/ kg, IM) from saline. Administration of various doses of cocaine resulted