Effects of selective D1 and D2 dopamine antagonists on cocaine self-administration in the rat
โ Scribed by Carol B. Hubner; J. Edward Moreton
- Publisher
- Springer
- Year
- 1991
- Tongue
- English
- Weight
- 991 KB
- Volume
- 105
- Category
- Article
- ISSN
- 0033-3158
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The present study used autoradiography to examine the effects of chronic self-administration of cocaine on the density of dopamine D 2 receptors in nonhuman primates. Three rhesus monkeys intravenously self-administered an average of 1.35 mg/kg cocaine per day for 18-22 months until they were euthan
An array of evidence indicates that long-term exposure to cocaine alters several components of the brain dopamine system. Because the release of dopamine in the nucleus accumbens (NAc) has been implicated in mediating the reinforcing effects of cocaine, changes in dopamine function can have profound