𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Effects of CIS-platinum on embryonal carcinoma cell lines in vitro

✍ Scribed by J. W. Oosterhuis; P. W. Andrews; B. B. Knowles; I. Damjanov

Publisher
John Wiley and Sons
Year
1984
Tongue
French
Weight
879 KB
Volume
34
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Human and mouse embryonal carcinoma (EC) cells lines were compared with several cell lines of a more differentiated phenotype for their relative sensitivities to the cytotoxic effects of cis‐platinum (cis‐diamine‐dichloroplatinum; CDDP); EC lines were among the most sensitive. Furthermore, several markers of EC cell differentiation were not induced by CDDP, irrespective of the concentration of the drug used. These data provide an explanation for the relative sensitivity of the EC cells in non‐seminomatous germ‐cell tumors to cis‐platinum therapy.

📜 SIMILAR VOLUMES

Effects of tamoxifen on telomerase activ
Effects of tamoxifen on telomerase activity in breast carcinoma cell lines
✍ Wade K. Aldous; Amber J. Marean; Mary J. DeHart; Louis A. Matej; Katherine H. Mo 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 178 KB 👁 2 views

The authors tested the effects of the antiestrogenic agent tamoxifen on telomerase activity and cell proliferation in MCF-7 and MDA-MB-231 breast carcinoma cell lines. MCF-7 cells belong to a known estrogen receptor positive cell line, whereas MDA-MB-231 cells, previously thought to be estrogen rece

in vitro effects of recombinant human in
in vitro effects of recombinant human interferon gamma on human mesothelioma cell lines
✍ L. Zeng; A. Buard; L. Saint-Etienne; M. C. Jaurand; J. Bignon; I. Monnet; P. Bro 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 French ⚖ 722 KB

Malignant mesothelioma is a tumor arising from serous surfaces and often related to asbestos exposure. Malignant mesothelioma is resistant to various forms of therapy. Radiotherapy, surgery or chemotherapy only slightly improve prognosis. IFN-y produces complete or partial responses in stage-I patie

DNA-binding properties of novel cis- and
DNA-binding properties of novel cis- and trans platinum-based anticancer agents in 2 human ovarian carcinoma cell lines
✍ Kirste J. Mellish; Christopher F. J. Barnard; Barry A. Murrer; Lloyd R. Kelland 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 French ⚖ 760 KB

## Abstract We have investigated the comparative initial DNA binding properties of 7 platinum‐based anticancer drugs: 5 __cis__‐oriented compounds, cisplatin, tetraplatin (Ormaplatin), JM118 [__cis__ ammine dichloro (cyclohexylamine) platinum (II)], JM216 [bis‐acetato __cis__ ammine dichloro (cyclo

Effects of presensitization in vivo on c
Effects of presensitization in vivo on cell-mediated responses to embryonic antigens in vitro
✍ K. Nelson; H. O. Sjögren 📂 Article 📅 1978 🏛 John Wiley and Sons 🌐 French ⚖ 767 KB

## Abstract Lymphoid cells specifically reactive with antigens shared by rat bowel carcinomas and mid‐term embryo cells were generated by __in vitro__ culture on monolayers of embryo cells. Spleen cells from WF females were cultured for 5 days on monolayers of syngeneic embryo cells or adult cells

Effect of bone proteins on human prostat
Effect of bone proteins on human prostate cancer cell lines in vitro
✍ Hullinger, Thomas G.; McCauley, Laurie K.; DeJoode, Melanie L.; Somerman, Martha 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 290 KB 👁 2 views

## Background: Despite the high incidence and serious consequences of skeletal metastasis in prostate cancer patients, the mechanisms involved in establishing secondary lesions in bone are not well-understood. in this study, the role of the mineralized bone matrix in the process of skeletal metasta