✦ LIBER ✦

Effects of alkaloids from Corydalis decumbens on contraction and electrophysiology of cardiac myocytes

✍ Scribed by Shigetoshi Kadota; Xiao-Li Sun; Purusotam Basnet; Tsuneo Namba; Yasunori Momose

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 466 KB
Volume: 10
Category: Article
ISSN: 0951-418X
DOI: 10.1002/(sici)1099-1573(199602)10:1<18::aid-ptr765>3.0.co;2-k

No coin nor oath required. For personal study only.

✦ Synopsis

The chloroform extract of Corydalis decumbens significantly increased the beating amplitude of cultured myocardial cell sheets. Chemical analysis led to the isolation of isoquinoline and protopine alkaloids. Of these isolated alkaloids, corlumidine and ( + )-adlumidine increased the beating amplitude, but ( + )-egenine decreased the beating rate and beating amplitude while protopine did not show any activity. We also studied the effects of (+)-egenine and corlumidine on contractile responses and Ca2+ currents in single bullfrog atrial cells using the voltage-clamp method. (+)-Egenine inhibited Ca2+ current by 68% of the control in single cell of bullfrog atrium, while corlumidine increased Ca2+ current to 60% at a concentration of 0.03 mM.

📜 SIMILAR VOLUMES

Electrophysiological effects of Gallanil

Electrophysiological effects of Gallanilide on cardiac ventricular and Purkinje fibers

✍ Xu Shang-Zhong; Zhu Xin-Ying; Yan Shou-Qi 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 103 KB

The effects of gallanilide on action potentials were studied in swine ventricular muscles, Purkinje fibers, and guinea pig papillary muscles by conventional microelectrode techniques. Gallanilide (l-l0 µM) prolonged the action potential duration (APD) and effective refractory period (ERP) in ventric

Effects of 1-pyrrolidinylmethyl-2-naphth

Effects of 1-pyrrolidinylmethyl-2-naphthol on contractile force and ionic current in cardiac and vascular smooth myocytes

✍ Ai-Yu Shen; Sheng-Nan Wu 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 191 KB

Ionic mechanisms of the cardiovascular actions of 1-pyrrolidinylmethyl-2-naphthol hydrochloride (TPY-β) were examined. Intravenous infusion of TPY-β produced hypotension and bradycardia in a dose-dependent manner. TPY-β (30 µM) produced biphasic change in contractile force in isolated rat atria, i.e

Effects of sulfonylureas on mitochondria

Effects of sulfonylureas on mitochondrial ATP-sensitive K+ channels in cardiac myocytes: implications for sulfonylurea controversy

✍ Toshiaki Sato; Hirofumi Nishida; Masaru Miyazaki; Haruaki Nakaya 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 326 KB

Different Effects of Some Isoquinoline A

Different Effects of Some Isoquinoline Alkaloids from Argemone mexicana on Electrically Induced Contractions of Isolated Guinea-pig Ileum

✍ Sonia Piacente; Anna Capasso; Nunziatina De Tommasi; Cumanda Jativa; Cosimo Pizz 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 124 KB 👁 2 views

The present study examines the effects of the extracts [petroleum ether, CHCl 3 , CHCl 3 /MeOH (9:1) and MeOH], partially purified fractions and pure compounds from Argemone mexicana on the electrically induced contractions of the isolated guinea-pig ileum (E.C.I.). The results of the experiments i

Effects of relativity and of the lanthan

Effects of relativity and of the lanthanide contraction on the atoms from hafnium to bismuth

✍ Paul S. Bagus; Yoon S. Lee; Kenneth S. Pitzer 📂 Article 📅 1975 🏛 Elsevier Science 🌐 English ⚖ 310 KB

In order to help elucidate the effect of the 4f shell of electrons, Hnrtree-Fock (HF) calcuhtions \Vcie made for the pseudo-atoms corresponding to Hf, Re, Au, Hg, TI, Pb, and Bi without 4f electrons and with atomic numbers reduced by 14. The orbital enerzje:; for these pseudo-atoms are compared with

In vivo effects of sera from Guillain-Ba

In vivo effects of sera from Guillain-Barré subgroups: An electrophysiological and histological study on rat nerves

✍ Dr. Peter G. Oomes; MD Phd Frans G. A. Van Der Meché; Loes Markus-Silvis; MD Jan 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 799 KB

Serum from 20 patients with Guillain-Barr6 syndrome (GBS), 10 healthy controls and 10 patients with recent cytomegalovirus, Epstein-Barr virus, or Campylobacter jejunilcoli infections was injected into rat sciatic nerve. The 20 GBS patients consisted of 2 groups of 10 patients with different electro