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Electrophysiological effects of Gallanilide on cardiac ventricular and Purkinje fibers

✍ Scribed by Xu Shang-Zhong; Zhu Xin-Ying; Yan Shou-Qi

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
103 KB
Volume
40
Category
Article
ISSN
0272-4391

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✦ Synopsis

The effects of gallanilide on action potentials were studied in swine ventricular muscles, Purkinje fibers, and guinea pig papillary muscles by conventional microelectrode techniques. Gallanilide (l-l0 Β΅M) prolonged the action potential duration (APD) and effective refractory period (ERP) in ventricular muscles and Purkinje fibers. The ratio of ERP/APD 90 increased. The slopes of phase l and phase 3 of action potential were flattened. Gallanilide (l0 Β΅M) decreased the maximal rising rate and amplitude of the action potential. The depressant effect on the maximal rising rate was frequency-dependent. These results suggest that gallanilide possesses both class I and III antiarrhythmic actions, which may be the electrophysiological basis of its antiarrhythmic effect. Drug Dev. Res. 40:94-98, 1997.

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