✦ LIBER ✦

Effects of activating transcription factor 4 deficiency on carbohydrate and lipid metabolism in mammals

✍ Scribed by Chunxia Wang; Feifan Guo

Publisher: John Wiley and Sons
Year: 2012
Tongue: English
Weight: 724 KB
Volume: 64
Category: Article
ISSN: 1521-6543
DOI: 10.1002/iub.605

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

It has been shown that the mammalian activating transcription factor 4 (ATF4) is involved in many different physiological events, such as eye development, stress response, learning, and memory. However, several recent studies have demonstrated that ATF4 also plays an important role in the regulation of lipid and glucose metabolism, energy homeostasis, insulin secretion, and sensitivity, suggesting that ATF4 is a master regulator of metabolism. This review summarizes the most recent progress in the understanding of the novel roles of ATF4 in the regulation of metabolism. © 2012 IUBMB IUBMB Life, 2012.

📜 SIMILAR VOLUMES

Studies on rumen metabolism. III.—Effect

Studies on rumen metabolism. III.—Effect of lipids in vitro and in vivo on microbial activity

✍ J. A. Robertson; J. C. Hawke 📂 Article 📅 1964 🏛 John Wiley and Sons 🌐 English ⚖ 633 KB

Effects of vitamin E deficiency on hepat

Effects of vitamin E deficiency on hepatic mitochondrial lipid peroxidation and oxidative metabolism in rats with chronic dietary iron overload

✍ Bruce R. Bacon; Robert S. Britton; Rosemary O'Neill 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 799 KB

In both hereditary hemochromatosis (HHC) and in the various forms of secondary hemochromatosis, there is a pathological expansion of total body iron stores, due mainly to an inappropriate increase in absorption of dietary iron (1-3). The liver is the major recipient of this excess absorbed iron, and

Effects of glutamine on proinflammatory

Effects of glutamine on proinflammatory gene expression and activation of nuclear factor kappa B and signal transducers and activators of transcription in TNBS-induced colitis

✍ Nelson A. Kretzmann; Henrique Fillmann; José L. Mauriz; Claudio Augusto Marroni; 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 545 KB

## Background: We investigated the effects of glutamine on proinflammatory gene expression and activation of nuclear factor kappa B (NF-B) and signal transducers and activators of transcription (STAT) in a rat model of experimental colitis. ## Methods: Colitis was induced in male Wistar rats by i

Hypolipidemic activity of tetrakis-μ-(tr

Hypolipidemic activity of tetrakis-μ-(trimethylamine-boranecarboxylato)-bis(trimethylamine-carboxyborane)-dicopper(II) in rodents and its effect on lipid metabolism

✍ I. H. Hall; W. L. Williams Jr.; Colleen J. Gilbert; A. T. McPhail; B. F. Spielvo 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 English ⚖ 602 KB

Discordant effects of activator protein-

Discordant effects of activator protein-1 transcription factor on gene regulation, invasion, and metastasis in spontaneous, radiation-induced, and fos-induced osteosarcomas

✍ Brigitte Rupp; Ursula Lorenz; Jörg Schmidt; Anne Katrin Werenskiold 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 237 KB 👁 1 views

Bone cells are a prime target for the biological function of the fos/jun (activating protein-1 (AP-1)) transcription factor complex. Deregulated expression of c-fos or v-fos in bone cells induces tumorigenicity and the formation of non-metastatic osteosarcomas. In contrast, fos oncogenes transform f

Effects of peritoneal injection of NH4HC

Effects of peritoneal injection of NH4HCO3 on nitrogen excretion and metabolism in the swamp eelmonopterus albus? increased ammonia excretion with an induction of glutamine synthetase activity

✍ Lim, Chiat Koo ;Chew, Shit Fun ;Tay, Angeline Su Ling ;Ip, Yuen Kwong 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 208 KB

Monopterus albus has to deal with high environmental ammonia concentrations during dry seasons and agricultural fertilization in rice fields. In this study, NH 4 HCO 3 (10 mmol per g fish) was injected into the peritoneal cavity of M. albus, raising the level of ammonia in the body, in order to eluc