We describe a new, efficient synthesis of DX-9065a (4), a potent inhibitor of the blood coagulation enzyme factor Xa (fXa) which has previously been prepared in more than 20 steps. We saved approximately 10 steps starting with a Pd-catalyzed cyanation of the triflate 10 of 7-methoxynaphthalen-2-01 (
β¦ LIBER β¦
Effects of a factor Xa inhibitor, DX-9065a, in a novel rabbit model of venous thrombosis
β Scribed by K.L. Rogers; L. Chi; S.T. Rapundalo; J.B. Kramer; K.P. Gallagher
- Publisher
- Springer
- Year
- 1999
- Tongue
- English
- Weight
- 158 KB
- Volume
- 94
- Category
- Article
- ISSN
- 0300-8428
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
A Short Synthesis of the Factor-Xa Inhib
β
Christiane Kehr; Richard Neidlein; Richard A. Engh; Hans Brandsretter; Ralf Kucz
π
Article
π
1997
π
John Wiley and Sons
π
German
β 316 KB
Molecular model of an interaction betwee
β
S Katakura; T Nagahara; T Hara; S Kunitada; M Iwamoto
π
Article
π
1995
π
Elsevier Science
π
French
β 801 KB
ChemInform Abstract: A Short Synthesis o
β
C. KEHR; R. NEIDLEIN; R. A. ENGH; H. BRANDSTETTER; R. KUCZNIERZ; H. LEINERT; K.
π
Article
π
2010
π
John Wiley and Sons
β 34 KB
π 1 views
Antithrombotic effects of YM466, a synth
β
Yoshiyuki Iwatsuki; Seiji Kaku; Yumiko Moritani; Yuta Taniuchi; Fukushi Hirayama
π
Article
π
2003
π
John Wiley and Sons
π
English
β 88 KB
## Abstract The antithrombotic effects of YM466, a synthetic direct inhibitor of human factor Xa (FXa), were evaluated in an arterioβvenous shunt thrombosis model in squirrel monkeys. YM466 significantly inhibited thrombus formation after continuous IV zx infusion at doses of 3β30 Β΅g/kg/h. Although
Hepatobiliary transport of YM466, a nove
β
Yuji Mano; Takashi Usui; Hidetaka Kamimura
π
Article
π
2006
π
Springer-Verlag
π
English
β 731 KB
Absorption, distribution, metabolism and
β
Yuji Mano; Takuya Sonoda; Eiji Nakamura; Takashi Usui; Hidetaka Kamimura
π
Article
π
2004
π
John Wiley and Sons
π
English
β 101 KB
π 2 views