We describe a new, efficient synthesis of DX-9065a (4), a potent inhibitor of the blood coagulation enzyme factor Xa (fXa) which has previously been prepared in more than 20 steps. We saved approximately 10 steps starting with a Pd-catalyzed cyanation of the triflate 10 of 7-methoxynaphthalen-2-01 (
β¦ LIBER β¦
ChemInform Abstract: A Short Synthesis of the Factor-Xa Inhibitor DX-9065a Using Palladium- Catalyzed Key Steps.
β Scribed by C. KEHR; R. NEIDLEIN; R. A. ENGH; H. BRANDSTETTER; R. KUCZNIERZ; H. LEINERT; K. MARZENELL; K. STREIN; W. VON DER SAAL
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 34 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0931-7597
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