## Abstract Female SpragueβDawley rats were given a subcutaneous injection of the parent hydrocarbon or its Kβregion epoxide in 0.1 ml sesame oil on alternate days to a total of 30 doses and observed for sarcoma at the site of injection for 275 days. The parent compounds, benzo(a)__pyrene (0.2 ΞΌmol
Effects of 7,12-dimethylbenz[a]anthracene, benzo[a]pyrene and cyclosporin A on murine cytomegalovirus infection: Studies of resistance mechanisms
β Scribed by Mary Jane K. Selgrade; Mary J. Daniels; Gary R. Burleson; Lloyd D. Lauer; Jack H. Dean
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 604 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0192-0561
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The presence of ER in DMBA-tumors was demonstrated by the use of dextrancharcoal assay, sephadex chromatography, sucrose gradient sedimentation, and organ culture techniques. It was found that tumors have binding sites ranging from 10-" to 10-l' moles/mg protein, and a dissociation constant of ER 10
Wistar rats of different age and sex received a single intragastric instillation of ## 7,12-dimethylbenz(a)anthracene ( D M B A ) . During the following 16 months, 136 of 284 rats developed 182 tumors, of which haw were malignant. Among 98 untreated controls, 8 rats developed tumors, of which 4 w