𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Effectiveness of extreme discordant sib pairs to detect oligogenic disease loci

✍ Scribed by John J. Rogus; David P. Harrington; Eric Jorgenson; Xiping Xu

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
50 KB
Volume
14
Category
Article
ISSN
0741-0395

No coin nor oath required. For personal study only.

✦ Synopsis

A method for the genomic screening of quantitative traits using extreme discordant sib pairs (EDSPs) has recently been described by Risch and Zhang [1995;1996]. For many models relevant to common, genetically complex diseases, EDSPs are the most powerful siblings for detecting linkage. Thus, if such siblings can be identified and collected, powerful studies with reasonable genotyping budgets can be conducted. Using a subset of the GAW10 data, we have simulated a genomic screen using EDSPs. From the 4,780 total families in the first 20 replicates of 239 families, there were 100, 104, 155, 107, and 180 EDSP families for Q1, Q2, Q3, Q4, and Q5, respectively. EDSP data were analyzed for each trait using a modified version of MAPMAKER/SIBS capable of handling extreme discordant sib pairs. Four regions, one for Q1, one for Q2, and two for Q4, were able to exceed a threshold for linkage corresponding to a 0.001 pointwise significance level. In three cases, maximum lod score (MLS) peaks occurred within 3.8 cM of a major gene. In the fourth case, the MLS peak occurred 28.4 cM from a major gene. Omission of parents and an alternative definition of EDSP were also investigated.

πŸ“œ SIMILAR VOLUMES

The power of two-locus affected sib-pair
The power of two-locus affected sib-pair linkage analysis to detect interacting disease loci
✍ Ingileif B. HallgrΓ­msdΓ³ttir; Terence P. Speed πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 English βš– 124 KB πŸ‘ 1 views

## Abstract It has been shown that two‐locus linkage analysis can, for some two‐locus disease models, be used to detect effects at disease loci that do not reach significance in a genome scan. However, few examples exist where two‐locus linkage has been successfully used to map genes. We study the

Testing the utility of mod scores and si
Testing the utility of mod scores and sib-pair analysis to detect presence of disease susceptibility loci
✍ Rosalind J. Neuman; Hong Xian πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 38 KB πŸ‘ 2 views

Linkage analyses and association studies were employed to detect disease susceptibility loci leading to elevated Q1 levels in Problem 2B. Phenotypes were defined to be the dichotomous affection status, the quantitative value for Q1, and Q1 adjusted for covariates. The method of mod-scores (for the d

Multiple regression analysis of sib-pair
Multiple regression analysis of sib-pair data on reading to detect quantitative trait loci
✍ D. W. Fulker; L. R. Cardon; J. C. Defries; W. J. Kimberling; B. F. Pennington; S πŸ“‚ Article πŸ“… 1991 πŸ› Springer Netherlands 🌐 English βš– 736 KB

A simple extension of the DeFries and Fulker multiple regression model for twin analysis is applied to the problem of detecting linkage in a quantitative trait. The method, employing sib pairs, is based on that of Haseman and Elston. Reading data from 19 extended pedigrees were analyzed employing RL

Utility of the affected sib pair method
Utility of the affected sib pair method to detect linkage of a sex-linked dominant disease with a sex-linked recessive trait
✍ Ranajit Chakraborty πŸ“‚ Article πŸ“… 1989 πŸ› John Wiley and Sons 🌐 English βš– 304 KB πŸ‘ 1 views

Use of affected sib-pairs for linkage determination of a sex-linked dominant disease with a recessive X-chromosome marker will require extremely large sample sizes, particularly when the marker is marginally polymorphic. In addition, this method should not be used without caution on data collected f