A comparison of three affected-sib-pair scoring methods to detect HLA-linked disease susceptibility genes

Utility of the affected sib pair method

Utility of the affected sib pair method to detect linkage of a sex-linked dominant disease with a sex-linked recessive trait

✍ Ranajit Chakraborty 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 304 KB 👁 1 views

Use of affected sib-pairs for linkage determination of a sex-linked dominant disease with a recessive X-chromosome marker will require extremely large sample sizes, particularly when the marker is marginally polymorphic. In addition, this method should not be used without caution on data collected f